As a dog owner, it is important that you understand when and why Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as Rimadyl, Metacam and Deramaxx are necessary for your dog's well-being. The benefits of NSAIDs for dogs can be paramount for those suffering from arthritis or post-surgery pain, but it's as important to understand the risks before administering this type of medication. Educate yourself on potential hazards so your dog gets maximum relief without compromising safety. By reading on through this post, we’ll explore the basics of NSAIDs including their effects and side effects - helping you make an informed decision as a responsible pet parent.

What is an NSAID and how do they work?

Non-Steroidal Anti-inflammatory Drugs or NSAIDs are analgesics that are used to reduce inflammation and pain. By blocking the activity of the cyclooxygenase (COX) enzyme, which is responsible for producing prostaglandins—hormone-like substances that cause discomfort—NSAIDs for dogs can reduce painful symptoms caused by chronic conditions like arthritis or other painful conditions. Though NSAIDs for dogs can be beneficial, always consult with your veterinarian before administering them as side effects may occur when used improperly.

The most commonly used NSAIDs in dogs that provide good pain relief include:

  • Meloxicam (Metacam®)
  • Deracoxib (Deramaxx®)
  • Carprofen (Rimadyl®)
  • Firocoxib (Previcox®)
  • Robenacoxib (Onsior®)

Benefits and advantages of NSAIDs for dogs

NSAIDs for dogs have many benefits when used correctly and in the right doses. NSAIDs can help relieve pain and inflammation caused by arthritis, acute pain and injuries, post-surgery pain, and other chronic conditions. NSAIDs work quickly to reduce inflammation and discomfort, with effects often seen within the first few days of starting the medication. NSAIDs also have antipyretic (anti-fever) properties that make them useful for reducing fever in dogs.

NSAIDs for dogs

Furthermore, NSAIDs can provide a plethora of advantages for our canine companions, significantly boosting their quality of life. These medications go beyond the relief they bring through reducing pain and inflammation – when administered correctly, they can help alleviate discomfort while encouraging improved mobility and energy levels. Furthermore, by helping in post-operative care, these drugs facilitate accelerated healing to ensure dogs are feeling back up to speed soon after surgery!

Risks and disadvantages associated with NSAIDs for dogs

NSAIDs can be beneficial in relieving pain and inflammation for dogs, but there are potential risks involved. Among the most widespread side effects that pet owners should watch out for include vomiting, diarrhea, or even decreased appetite; However, these symptoms usually subside shortly after the medication is stopped.

Using NSAIDs can lead to serious consequences, such as gastrointestinal ulceration and bleeding, liver and kidney damage, or in rare circumstances, can be life-threatening. These risks are more likely to occur in dogs who are given NSAIDs for an extended period of time or at high doses or given incorrectly. Senior dogs, as well as dogs with existing liver or kidney disorders and those taking additional medications that could interact negatively with NSAIDs, may be particularly vulnerable when it comes to the potential side effects of these drugs.

Collaborating with your veterinarian is essential for dog owners looking to use NSAIDs as the best way to manage their dog's pain and inflammation. Your vet can select an optimal dosage tailored specifically according to your pup, while also monitoring side effects or recommending alternate treatments should they be relevant - like physiotherapy or other medications.

How can you reduce the potential side effects of NSAIDs in dogs?

When NSAIDs are administered correctly, and for the smallest amount of time necessary to control symptoms, the risks associated with them decrease. To minimize potential side effects, it’s important to follow your veterinarian’s directions closely and never exceed the recommended dosage or duration of use.

Additionally, it's important to remember several steps when using NSAIDs in dogs. When administering the medication, always combine it with food as this can help reduce gastrointestinal side effects. Additionally, be sure to check if other medications interact before giving a dog an NSAID and avoid use for dogs already suffering from pre-existing liver or kidney issues. Most veterinarians will recommend blood testing before using NSAIDs long-term and following up with yearly checks thereafter.

It is also important to understand the importance of a 7-day washout period when switching NSAIDs for dogs. This period helps reduce the risk of potential side effects, as it allows time for any remaining NSAID in the dog’s system to be eliminated before starting a new NSAID therapy. During this time, it is recommended that you monitor your pet closely and contact your veterinarian if any concerning symptoms arise.

How are NSAIDs dosed and administered to dogs?

NSAIDs are most commonly available as a liquid or chewable tablet. Your veterinarian can use injectable versions of the medication for added convenience and expedited benefits.

The most appropriate NSAID for your dog will depend on their individual needs as outlined by your veterinarian. NSAIDs for dogs are typically dosed once daily, every 24 hours, although your veterinarian may prescribe an alternate interval if necessary. As mentioned previously, NSAIDs should be given with food to help reduce any potential adverse effects.

When should NSAIDs NOT be used in dogs?

NSAIDs can be beneficial in treating pain and inflammation when used properly, but pet owners must take precautions. For example, these medications should not be given to pregnant or nursing dogs as they may have negative effects on developing fetuses and newborn puppies.

Additionally, NSAIDs should not be given to dogs who have a history of gastrointestinal ulcers or bleeding, as they can increase the risk of these conditions. Dogs with pre-existing liver or kidney disease are also at an increased risk for adverse effects from NSAID use. It's important for pet owners to discuss any potential contraindications with their veterinarian before using NSAIDs to manage their dog's pain and inflammation. 

NSAIDs for dogs should not be used concurrently with steroid medications such as prednisone as they can greatly increase the risk of adverse effects. NSAIDs should also not be used in conjunction with other NSAIDs as this may increase the risk of side effects or toxicity.

FAQs about NSAID use in dogs

Is there a loading dose required?

Yes, NSAIDs for dogs typically require a loading dose when they are first used and is usually double the maintenance dose. This is because NSAIDs are protein bound in the bloodstream, so a higher initial dose is necessary to reach effective levels. Your veterinarian will advise the proper NSAID loading dose based on your pet’s individual needs.

Can NSAIDs be used long-term?

Yes, in some cases NSAIDs may be prescribed for long-term use. Frequent monitoring of internal functions, especially liver and kidney blood values is important to maintain safety and avoid adverse effects.

Are there over-the-counter (OTC) versions of NSAIDs for dogs?

No, NSAIDs for dogs should only be used under the specific guidance and instruction of a veterinarian. Common human NSAIDs such as ibuprofen should not be used in dogs as these medications can be toxic to dogs.

What are the symptoms of an adverse effect of NSAIDs in dogs?

Serious symptoms such as blood in vomit or black stools suggest bleeding in the stomach or intestines. Other symptoms such as lack of appetite (anorexia), increased thirst and urination, and lethargy may indicate NSAID toxicity. If you observe any of these signs in your pet, contact your veterinarian immediately.


NSAIDs for dogs can be a great way to manage pain and inflammation, but pet owners must take certain precautions. NSAIDs should only be used when prescribed by your veterinarian, who will determine the correct dosage tailored for your dog's individual needs. Additionally, NSAIDs should not be given to dogs with a history of gastrointestinal signs as well as those with pre-existing liver or kidney issues. It is also important to remember that there should always be a 7-day washout period between switching NSAID medications and other drugs such as corticosteroids should not typically be taken concurrently with NSAIDs for safety reasons. Following these tips can help ensure you are taking proper care of your pup’s health while using NSAIDs responsibly! If you have any further questions, please contact your veterinarian.