Unfortunately, intestinal lymphoma is a type of cancer that commonly affects cats. It begins in the intestinal tract and can spread to other parts of the body if left untreated. Unfortunately, this type of cancer is difficult to identify as the symptoms are similar to other gastrointestinal diseases such as inflammatory bowel disease (IBD). As a cat owner, it's important to be aware of the signs and symptoms of intestinal lymphoma in cats, as early detection can increase your cat's chances of survival. In this article, we will explore everything there is to know about intestinal lymphoma in cats - from causes and symptoms to diagnosis and treatment options. Let's dive in!

Causes and risk factors for intestinal lymphoma in cats

The exact cause of intestinal lymphoma in cats is uncertain, although there may be a connection between chronic intestinal inflammation, such as inflammatory bowel disease (IBD), and the development of this cancer. This inflammation is thought to create a microenvironment that encourages the growth and proliferation of abnormal cells, which can eventually lead to the formation of tumours in the intestinal tract.

Due to this potential link, it is crucial for cat owners to be aware of any symptoms of IBD or intestinal inflammation in their pets and to seek veterinary attention immediately if they believe their cat may be at risk for intestinal lymphoma.

What are the symptoms of intestinal lymphoma in cats?

Intestinal lymphoma in cats can present a range of symptoms that may vary depending on the type, location, and severity of the disease. Although some cats may show subtle or nonspecific signs, it is essential to be aware of the potential symptoms to ensure early detection and prompt intervention.

The following are some of the common symptoms associated with intestinal lymphoma in cats:

  • Weight loss: Unexplained weight loss is often one of the first noticeable signs of intestinal lymphoma. This can occur due to a decreased appetite or malabsorption of nutrients as a result of the tumour's impact on the intestinal lining.
  • Vomiting and diarrhea: Cats with intestinal lymphoma may experience recurrent episodes of vomiting and/or diarrhea. These symptoms can stem from the tumour causing inflammation or obstruction within the digestive tract.
  • Anorexia: Some cats with intestinal lymphoma may lose their appetite altogether or display a decreased interest in food.

Other signs of possible signs of intestinal lymphoma in cats can include constipation, excessive hunger (polyphagia), a bloated abdomen and a general deterioration in body condition.

How is intestinal lymphoma diagnosed in cats?

Diagnosing intestinal lymphoma in cats involves several steps and tests to accurately identify the presence and extent of the disease. It is essential to rule out other gastrointestinal issues that might exhibit similar symptoms. The following diagnostic procedures are commonly used to determine whether a cat has intestinal lymphoma:

  • Physical examination and history: Your veterinarian will begin by conducting a thorough physical examination, assessing your cat's overall health and looking for signs of abdominal pain, swelling, or masses. They will also ask about the cat's medical history and any recent changes in behaviour or symptoms.
  • Blood tests: A complete blood count (CBC), blood chemistry panel, and tests for feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) may be performed to evaluate the cat's overall health and identify any underlying conditions that could contribute to the symptoms.
  • Imaging: Abdominal X-rays or ultrasounds can help visualize any masses, thickening of the intestinal wall, or abnormalities in the surrounding organs. This can provide valuable information about the location and size of the tumour, as well as the potential involvement of other organs.
  • Biopsy and histopathology: A definitive diagnosis of intestinal lymphoma typically requires obtaining a sample of the affected tissue for examination under a microscope. This can be achieved through endoscopy, where a thin, flexible tube with a camera and small instruments is inserted through the cat's mouth to visualize and collect tissue samples. Alternatively, a full-thickness biopsy may be performed during exploratory surgery. The tissue samples are then examined by a veterinary pathologist to confirm the presence of cancerous cells and determine the specific type of lymphoma.
  • Staging of the disease: If intestinal lymphoma is confirmed, additional tests may be conducted to determine the extent of the disease and whether it has spread to other organs or lymph nodes. This process, known as staging, can include further imaging such as CT scans or additional biopsies. Staging helps guide treatment decisions and provides insight into the cat's prognosis.

After a thorough diagnostic process, your veterinarian will discuss the findings, recommend an appropriate treatment plan, and provide guidance on managing the cat's condition. Early detection and accurate diagnosis are crucial in ensuring the best possible outcome for cats with intestinal lymphoma.

What are the treatment options for intestinal lymphoma in cats?

Treatment options for intestinal lymphoma in cats will depend on various factors, including the type, location, and stage of the disease, as well as the cat's overall health and age. The primary goal of treatment is to manage the disease, reduce symptoms, and improve the quality of life for the affected cat. The following are some common treatment options for intestinal lymphoma in cats:

Chemotherapy is the most common treatment approach for feline intestinal lymphoma. Chemotherapy involves using drugs to kill cancer cells or inhibit their growth. Several chemotherapy protocols are available, and the choice depends on the specific type of lymphoma, its aggressiveness, and the cat's overall health. Some chemotherapeutic drugs such as chlorambucil may be administered orally at home, every few days. In some cases, a combination of different chemotherapy drugs may be used to increase their effectiveness.

If the lymphoma is localized and has not spread extensively, surgery may be performed to remove the tumour or affected section of the intestine. Surgery is often followed by chemotherapy to eliminate any remaining cancer cells and reduce the risk of recurrence.

Corticosteroids, such as prednisolone, are commonly used in conjunction with chemotherapy or as a palliative treatment option for cats with intestinal lymphoma. Steroids can help reduce inflammation, improve appetite, and enhance the cat's overall well-being. However, they are not a curative treatment on their own.

Supportive care and nutritional management: Ensuring the cat's comfort and maintaining its nutritional needs is vital during the treatment process. This may involve providing a highly digestible, calorie-dense diet, administering anti-nausea medications, and ensuring proper hydration. Pain management and additional medications to control vomiting or diarrhea may also be prescribed, depending on the cat's symptoms.

It is important to maintain regular communication with your veterinarian throughout the treatment process, as adjustments to the treatment plan may be necessary depending on the cat's response and any side effects experienced. Early detection, prompt treatment, and ongoing monitoring are crucial in managing intestinal lymphoma and ensuring the best possible outcome for your feline friend.


In conclusion, intestinal lymphoma in cats is a challenging disease that requires early detection, prompt intervention, and ongoing care to ensure the best possible outcome for your beloved feline companion. By staying informed about the disease's symptoms, diagnostic procedures, and treatment options, you can take a proactive approach to safeguard your cat's health. Collaborate closely with your veterinarian to develop a personalized treatment plan tailored to your cat's unique needs and monitor their progress throughout the treatment journey. As a devoted cat owner, your support and dedication will make a significant difference in your furry friend's quality of life and overall well-being as they face this health challenge. If you have any further questions or are concerned about intestinal lymphoma affecting your cat, please contact your veterinarian.