Does your cat have a respiratory tract infection? Has your vet recently prescribed azithromycin and you're seeking more information about this medication? Azithromycin for cats, also known as Zithromax®, is a highly effective broad-spectrum antibiotic that is prescribed to treat a wide range of bacterial, parasitic, and rickettsial infections. In this article, we will explore the uses, the correct dosage, and potential side effects of Azithromycin for cats.

đź’Š Key Takeaways

  • Azithromycin is a long-lasting antibiotic commonly prescribed for respiratory infections in cats, making it convenient for less frequent dosing.
  • While generally well-tolerated, azithromycin may cause gastrointestinal upset like vomiting in cats.
  • Besides its antibacterial properties, azithromycin also has anti-inflammatory and immune-modulating effects, which can be beneficial in treating certain conditions.

What is azithromycin for cats and how does it work?

In technical terms, azithromycin is a semi-synthetic, lipid-soluble antibiotic that belongs to a group of medications known as macrolides. But don't let those big words intimidate you. Simply put, it's a medicine designed to fight off bacterial infections in your cat. It's most commonly used to treat various respiratory tract infections.

Azithromycin works by targeting the machinery inside bacterial cells through an action called "bacteriostatic," meaning it doesn't kill the bacteria outright but inhibits their growth and ability to spread.

When given to your cat, azithromycin is well-absorbed through the digestive system—about 60% of the medicine actually gets into your cat's bloodstream, which is a pretty good rate. Once in the body, it does an excellent job of spreading into tissues, even reaching white blood cells, which helps it fight off infections more effectively.

One of the unique things about azithromycin is its long-lasting effects. It has what's known as a "prolonged elimination half-life," meaning it stays in your cat's system for an extended period. This is why you might find that your vet prescribes doses that are spaced out over several days, rather than requiring daily administration.

Azithromycin not only fights bacterial infections, but it also possesses anti-inflammatory and immune-modulating properties.

When is azithromycin prescribed for cats?

If you're a cat owner, you might be wondering when a veterinarian would prescribe azithromycin for your cat. After all, antibiotics are powerful medications, and it's important to use them responsibly. Here, we'll discuss the situations where azithromycin might be the go-to choice for treating your cat's health issues.

One of the most common reasons azithromycin is prescribed for cats is to treat respiratory infections. If your cat is coughing, sneezing, or showing signs of a respiratory issue otherwise, and a bacterial infection is suspected, azithromycin could be a treatment option.

It's particularly effective against certain types of bacteria like Bordatella, Staphylococcus, Streptococcus, Mycoplasma, and Chlamydia bacteria which are often responsible for respiratory tract infections in cats.

Azithromycin for cats has also been found to be effective against less common but serious infections like toxoplasmosis and cryptosporidium. It can even be used in combination with another medication, atovaquone, to treat specific parasitic infections like Cytauxzoon felis.

Finally, azithromycin is also used in cats as a gastrointestinal pro-motility agent. It works by improving stomach contractions, increasing stomach emptying, and accelerating small intestine transit. These features also azithromycin to be used when treating stomach reflux and constipation in cats.

Azithromycin dosing for cats

To quickly reach effective concentrations in the body, a loading dose is often recommended. For azithromycin, a loading dose is often achieved by giving the medication once daily for 5 days before reduction.

One of the advantages of azithromycin is its long-lasting effects and therefore, most cats can be successfully dosed every 3 days when treating respiratory tract infections. When used for reasons other than respiratory tract infections, such as treating toxoplasmosis, your veterinarian may recommend daily dosing for 21 days.

Proper dosing is key to the success of any antibiotic treatment, and azithromycin is no exception. Always adhere to your veterinarian's instructions and complete the full course of treatment, even if your cat seems to be feeling better. This ensures that the bacterial infection has been completely cleared and reduces the risk of developing antibiotic resistance.

Azithromycin for cats is available in a tablet or oral suspension (liquid).

Potential side-effects of azithromycin

Like all medications, azithromycin can have some potential side effects in cats. These side effects are uncommon and usually mild but it's important to be aware of them.

The most common side effects reported in cats taking azithromycin include vomiting, diarrhea, and lack of appetite. If these symptoms persist or worsen, contact your veterinarian for further advice.

Other, much less common but more severe side effects may also occur. These could include hypersensitivity reactions such as swelling of the face or hives, liver toxicity, or changes in white blood cell counts. Although these specific side effects are uncommon, it is important to closely observe your cat throughout the treatment and promptly reach out to your veterinarian if you observe any unusual symptoms.

A summary of the benefits of azithromycin for cats

  • Effective treatment for upper respiratory infections
  • Can also be used to to treat stomach reflux and/or constipation
  • Potential use against Bartonella and protozoal microorganisms
  • Anti-inflammatory and immune-modulating effects
  • Longer tissue presence compared to other antibiotics
  • Relatively safe and well-tolerated in cats

Concerns and risk factors

Antibiotic resistance is common among macrolide antibiotics such as azithromycin. Prolonged or repeated antibiotic use can lead to superinfection caused by resistant organisms. To reduce this risk, antibiotics should only be used when necessary and as directed by a veterinarian.

Additionally, azithromycin is not suitable for cats with liver disease as this is where the majority of the medication is metabolized and excreted from the body. If your cat has a history of liver problems, make sure to inform your veterinarian before starting treatment.

You should avoid using it in cats with documented hypersensitivity to macrolide antibiotics such as azithromycin, clindamycin, or erythromycin.

FAQs

How long does it take for azithromycin to work?

You may start to see improvement within 24 to 48 hours. However, it's vital to complete the full course of medication as prescribed, even if your cat appears to feel better.

What should I do if I miss giving a dose?

If you miss a dose, administer it as soon as you remember. If it's close to the next scheduled dose, skip the missed one and continue with the regular schedule. Never double up on doses.

Can azithromycin interact with other medications?

Yes, azithromycin can interact with certain other medications, such as antacids and phenobarbital.


In conclusion, azithromycin is a potent and versatile medication frequently prescribed for cats to treat a variety of bacterial infections, particularly those affecting the respiratory tract. Its prolonged elimination half-life makes it a convenient option, often requiring doses spaced out over several days instead of daily administration. It also possesses anti-inflammatory and immune-modulating properties, thereby providing additional benefits. However, like any medication, azithromycin can have side effects, so it's important to observe your cat closely during treatment.